韩鹤友教授

prof.han

韩鹤友,博士,教授,博士生导师,华中农业大学研究生院常务副院长,农业微生物学国家重点实验室固定研究人员,华中农业大学化学生物学研究所所长,生物质与生物能源研究中心副主任,湖北省化学化工学会常务理事,农业部食品安全评价重点开放实验室副主任,教育部“新世纪优秀人才支持计划”获得者,武汉市学科带头人,湖北省创新团队带头人,美国化学会会员,《American Journal of Biomedical Sciences》、《分析科学学报》、《光散射学报》、《华中农业大学学报(自然科学版)》等杂志编委,享受国务院特殊津贴。

主要研究方向为农业纳米生物技术、食品安全分析等。主持包括国家自然科学基金在内的省部级以上科研课题10余项。2006年至2016年7月,以第一作者或通讯作者在Advanced Materials、Nature Communications、ACS Nano、Science Advances 、Advanced Functional Materials 、Analytical Chemistry、Chemical Communications、Nanoscale、Biosensor and Bioelectronics 等国内外重要期刊发表学术论文百余篇,其中影响因子大于5.0的近30篇,论文总被引用次数为1747次,个人H指数达24,授权专利11项,科研鉴定成果2项。

 

 

主持项目:

  1. 基于微流控芯片电化学发光检测的兽药残留分析新技术研究(新世纪优秀人才支持计划,NCET-05-0668);
  2. 量子点标记及成像技术用于猪链球菌2型的快速检测及致病机理研究(国家自然科学基金,20675034);
  3. 植物油脂绿色转化关键技术及产品(“863”重点项目,2007AA100703,承担其中“生物柴油磁性纳米固体碱催化剂的研制及配套生产技术研究” );
  4. 基于量子点标记的猪传染性胸膜肺炎快速诊断技术研究(武汉市学科带头人计划,200851430484);
  5. 近红外量子点成像用于Bt毒素受体确认及Bt杀虫机理研究(国家自然科学基金,20975042);
  6. 转基因动物抽样及快速、高通量检测技术体系研究(转基因生物新品种培养科技重大专项,2009ZX08012-015B子项目);
  7. 中美拉曼实时便捷检测装备化研究及食品安全与口岸应用(国际科技合作项目,2008DFA40270);
  8. 动物重大疫病纳米分子成像诊断及应用基础研究(湖北省自然科学基金创新群体项目,2011CDA115);
  9. 量子点双光子荧光成像技术用于猪圆环病毒2型致病机理研究(国家自然科学基金,21175051/B050902);
  10. 量子点近红外电致化学发光及其成像研究(国家自然科学基金,21375043/B050207)。

专利:

1. 韩鹤友,盛宗海,梁建功,一种小粒径水溶性硒化镉量子点的制备方法及用途,专利号:ZL 2005 1 0019940.6
2. 韩鹤友,郑新生,王运,文利柏,胡圣杨,生物柴油的一体化生产工艺及专用装置,专利号:ZL 2007 1 0052063.1
3. 韩鹤友,王运,郑新生,文利柏,胡圣杨,适用于制备生物柴油的纳米固体杂多酸、杂多碱催化剂及应用,专利号:ZL 2007 1 0052066.5
4. 韩鹤友,郑新生,王运,文利柏,胡圣杨,利用纳米固体杂多酸、杂多碱催化剂生产生物柴油的方法,专利号:ZL 2007 1 0052065.0
5. 韩鹤友,胡德红,周锐,董飞,贝为成,贾凡,梁建功,盛宗海,陈焕春,一种检测猪胸膜性肺炎抗体的胶体金化学发光免疫分析方法,专利号:ZL 2007 1 0052583.2
6. 韩鹤友,王运,胡圣扬,文利柏,关燕萍. 利用乌桕籽油制备生物柴油的方法及专用固体催化剂,专利号:ZL 2008 1 0046754.5
7. 韩鹤友,胡圣扬,王运. 一种棉酚快速检测试纸条及制备方法与应用,专利号:ZL 2009 1 0062827.4
8. 韩鹤友,原弘,陈坤. 一种可视化快速检测三聚氰胺的方法及其试剂盒,专利号:ZL 2009 1 0062894.6
9. 韩鹤友,张慧敏,何启盖,李文涛,盛宗海. 一种猪圆环病毒2型的乳胶凝集检测方法及应用,专利号:ZL 2010 1 0544496.0
10.韩鹤友,胡圣扬,周媛媛,付涛. 一种城乡生活垃圾绿色转化可再生能源的方法,专利号:ZL 2010 1 0570776.9
11.韩鹤友,谷小许,黄亮. CuInS2纳米晶及CuInS2/ZnS核壳结构纳米晶的制备方法,专利号:ZL 2012 1 0138338.4

 

近三年来发表的代表性论文(通讯作者):

1.Wenjing Wang,  Sha Yu, Shan Huang, Sai Bi,  Heyou Han*,Jian-Rong Zhang*, Yi Lu  and Jun-Jie Zhu*. Bioapplications of DNA nanotechnology at the solid–liquid interface[J]. Chemical Society Reviews, 2019.(IF:40.443)[download pdf]

2.Huajuan Wang, Zhiyong Song, Shuojun Li, Yang Wu, and Heyou Han*. One stone with two birds: functional gold nanostar for targeted combination therapy of drug resistant Staphylococcus aureus infection[J]. ACS applied materials & interfaces, 2019.(IF:8.456)[download pdf]

3. Jin Zhang, Mengqing Xu, Yongli Mu, Jinjie Li, Mohamed F. Foda, Weiyun Zhang, Kai Han and Heyou Han*.Reasonably retard O2 consumption through a photoactivity conversion nanocomposite for oxygenated photodynamic therapy[J]. Biomaterials, (2019): 119312.(IF:10.273)[download pdf]

4. Weiyun Zhang, Kai Cai, Xuyu Li, Jin Zhang, Zhaoyu Ma, Mohamed F Foda,    Yongli Mu, Xinxin Dai and Heyou Han*.Au Hollow Nanorods-Chimeric Peptide Nanocarrier for NIR-II Photothermal Therapy and Real-time Apoptosis Imaging for Tumor Theranostics[J]. Theranostics, 2019, 9.17: 4971.(IF:8.063)[download pdf]

5. Zhaoyu Ma, Long Wu,  Kai Han*and Heyou Han*.Pt Nanozyme for O2 Self-Sufficient, Tumor Specific Oxidative Damage and Drug Resistance Reversal[J]. Nanoscale Horizons, 2019.(IF:9.095)[download pdf]

6. Jiawei Liu, Shaoyan Wang, Kai Cai, Yefei Li, Zhipan Liu, Lingmei Liu, Yu Han,Hong Wang, Heyou Han* and Hongyu Chen*. A New Type of Capping Agent in Nanoscience: Metal Cations[J]. Small, 2019: 1900444.(IF:10.856)[download pdf]

7. Jinjie Li, Heng Yan, Xuecai Tan, Zhicheng Lu,and Heyou Han*.Cauliflower-Inspired 3D SERS Substrate for Multiple Mycotoxins Detection[J]. Analytical chemistry, 2019, 91.6: 3885-3892.(IF:6.35)[download pdf]

8. Zhiyong Song,  Huajuan Wang, Yang Wu,  Jiangjiang Gu,  Shuojun Li,  and Heyou Han*. Fabrication of Bis-Quaternary Ammonium Salt as an Efficient Bactericidal Weapon Against Escherichia coli and Staphylococcus aureus[J]. ACS omega, 2018, 3(10): 14517-14525.(IF:2.584)[download pdf]

9. Kai Cai,  Weiyun Zhang,  Jin Zhang,  Huiqiao Li, Heyou Han*, and Tianyou Zhai*. Design of Gold Hollow Nanorods with Controllable Aspect Ratio for Multimodal Imaging and Combined Chemo-Photothermal Therapy in the Second Near-Infrared Window[J]. ACS applied materials & interfaces, 2018, 10(43): 36703-36710.(IF:8.456)[download pdf]

10. Kang Shao, Biru Wang, Axiu Nie, Shiyi Ye, Jing Ma, Zhonghua Li, Zhicheng Lv, and Heyou Han*. Target-triggered signal-on ratiometric electrochemiluminescence sensing of PSA based on MOF/Au/G-quadruplex[J]. Biosensors and Bioelectronics, 2018, 118: 160-166.(IF:9.518)[download pdf]

11.Ting Du, Jian Lu, Lingzhi Liu, Nan Dong, Liurong Fang, Shaobo Xiao* and Heyou Han*, Antiviral Activity of Graphene Oxide–Silver Nanocomposites by Preventing Viral Entry and Activation of the Antiviral Innate Immune Response[J]. ACS Applied Bio Materials, 2018, 1(5): 1286-1293.(IF:。。)[download pdf]

12.Ting Du, Nan Dong, Liurong Fang,Jian Lu, Jing Bi, Shaobo Xiao* and Heyou Han*, Multisite Inhibitors for Enteric Coronavirus: Antiviral Cationic Carbon Dots Based on Curcumin[J]. ACS Applied Nano Materials, 2018, 1(10): 5451-5459.(IF:。。)[download pdf]

13.Xinxin Dai,Kai Han,Zhaoyu Ma,and Heyou Han*.A Chimeric Peptide Logic Gate for Orthogonal Stimuli-Triggered Precise Tumor Therapy[J]. Advanced Functional Materials , 2018:  1804609.(IF:15.621)[download pdf]

14.Jin Zhang ,Yongli  Mu , Zhaoyu Ma , Kai Han,and Heyou Han*. Tumor-triggered transformation of chimeric peptide for dual-stage-amplified magnetic resonance imaging and precise photodynamic therapy[J]. Biomaterials, 2018, 182:269.(IF:10.273)[download pdf]

15. Kai Han, Zhaoyu Ma, Xinxin Dai, Jin Zhang, and Heyou Han*. Steric shielding protected and acidity-activated pop-up of ligand for tumor enhanced photodynamic therapy[J]. Journal of Controlled Release, 2018, 279: 198-207.(IF:7.901)[download pdf]

16. Zhaoyu Ma, Kai Han*, Xinxin Dai, and Heyou Han*. Precisely Striking Tumor without Adjacent Normal Tissue Damage via Mitochondria-Templated Accumulation[J]. ACS nano, 2018, 12 (6): 6252-6262.(IF:13.903)[download pdf]

17.Jing Ma , Long Wu, Zhonghua Li, Zhicheng Lu, Wenmin Yin, Axiu Nie, Fan Ding, Biru Wang,and Heyou Han*. Versatile Electrochemiluminescence Assays for PEDV Antibody Based on Rolling Circle Amplification and Ru-DNA Nanotags[J]. Analytical chemistry, 2018, 90 (12): 7415-7421.(IF:6.35)[download pdf]

18. Zhiyong Song, Yang Wu, Qi Cao, Huajuan Wang, Xiangru Wang, and Heyou Han*. pH-Responsive, Light-Triggered on-Demand Antibiotic Release from Functional Metal–Organic Framework for Bacterial Infection Combination Therapy[J]. Advanced Functional Materials , 2018: 1800011.(IF:15.621)[download pdf]

19. Long Wu, Jiamin Deng, Xuecai Tan , Wenmin Yin, Fan Ding,and Heyou Han*. Ratiometric fluorescence sensor for the sensitive detection of Bacillus thuringiensis transgenic sequence based on silica coated supermagnetic nanoparticles and quantum dots[J]. Sensors and Actuators B: Chemical, 2018, 254: 206-213.(IF:6.393)[download pdf]

20.Wenmin Yin‡, Long Wu‡, Fan Ding, Qin Li,Pan Wang,Jinjie Li,Zhicheng Lv, and Heyou Han*. Surface-imprinted SiO2 @Ag nanoparticles for the selective detection of BPA using surface enhanced Raman scattering[J]. Sensors & Actuators B Chemical, 2018, 258: 566-573.(IF:6.393)[download pdf]

21.Ting Du, Jiangong Liang ,Nan Dong , and Heyou Han*. Glutathione-capped Ag2S nanoclusters inhibit coronavirus proliferation through blockage of viral RNA synthesis and budding[J]. ACS applied materials & interfaces, 2018, 10(5): 4369-4378.(IF:8.456)[download pdf]

22.Kai Han , Zhaoyu Ma ,and Heyou Han*. Functional peptide-based nanoparticles for photodynamic therapy[J]. Journal of Materials Chemistry B, 2018, 6(1): 25-38.(IF:5.047)[download pdf]

23. Long Wu, Jiamin Deng, Xuecai Tan, Wenmin Yin, Fan Ding and Heyou Han*. Ratiometric fluorescence sensor for the sensitive detection of Bacillus thuringiensis transgenic sequence based on silica coated supermagnetic nanoparticles and quantum dots[J]. Sensors and Actuators B: Chemical, 2018, 254: 206-213. (IF:5.401)[download pdf]

24.Wenmin Yin, Long Wu, Fan Ding, Qin Li, Pan Wang, Jinjie Li, Zhicheng Lv and Heyou Han*. Surface-imprinted SiO2 @Ag nanoparticles for the selective detection of BPA using surface enhanced Raman scattering[J]. Sensors & Actuators B Chemical, 2018, 258: 566-573. (IF:5.401)[download pdf]

25.Yunpeng Zuo, Dewei Rao, Shuo Li, Tingting Li, Guilin Zhu, Shuangming Chen, Li Song,  Yang Chai, and Heyou Han*. Atomic Vacancies Control of Pd-Based Catalysts for Enhanced Electrochemical Performance[J]. Advanced Materials, 2017,30(1) ,1704171. (IF:19.791) [download pdf]

26. Kai Han, Jin Zhang, Weiyun Zhang, Shibo Wang, Luming Xu, Chi Zhang, Xianzheng Zhang, and Heyou Han*. Tumor-Triggered Geometrical Shape Switch of Chimeric Peptide for Enhanced in Vivo Tumor Internalization and Photodynamic Therapy[J]. ACSNano, 2017, 11(3): 3178-3188. (IF:13.942)[download pdf]

27. Kai Han, Weiyun Zhang, Zhaoyu Ma, Shibo Wang, Luming Xu, Jia Liu, Xianzheng Zhang, and Heyou Han*.  Acidity-Triggered Tumor Retention/Internalization of Chimeric Peptide for Enhanced Photodynamic Therapy and Real-Time Monitoring of Therapeutic Effects[J]. ACS Applied Materials & Interfaces, 2017, 9(19): 16043-16053. (IF:7.504)[download pdf]

28. Zhaodong Yuan, Zhongming Zhang, Xiuping Wang, Li Li, Kai Cai and Heyou Han*. Novel impacts of functionalized multi-walled carbon nanotubes in plants: promotion of nodulation and nitrogenase activity in the rhizobium-legume system[J]. Nanoscale, 2017, 9(28): 9921-9937. (IF:7.367) [download pdf]

29.Qin Li, Zhicheng Lu, Xuecai Tan, Xiaoyan Xiao, Pan Wang, Long Wu, Kang Shao, Wenmin Yin, Heyou Han*. Ultrasensitive detection of aflatoxin B1 by SERS aptasensor based on exonuclease-assisted recycling amplification. Biosensors and Bioelectronics, 2017, 97: 59-64(IF:7.780)[download pdf]

30. Dian Li, Kai Cai, Long Wu, Yunpeng Zuo, Wenmin Yin, Huan Zhang, Zhicheng Lu, Guilin Zhu, and Heyou Han*. Ammonia Mediated One-Step Synthesis of Three-Dimensional Porous PtxCu100-x Nanochain Networks with Enhanced Electrocatalytic Activity toward Polyhydric Alcohol Oxidation[J]. ACS Sustainable Chemistry & Engineering, 2017, 5(11): 11086-11095. (IF:5.951)[download pdf]

31. Kai Han , Weiyun  Zhang , Jin Zhang , Zhaoyu Ma, and Heyou Han*. pH‐Responsive Nanoscale Coordination Polymer for Efficient Drug Delivery and Real‐Time Release Monitoring[J]. Advanced Healthcare Materials, 2017, 6(19): 1700470. (IF:5.110)[download pdf]

32. Long Wu, Fan Ding, Wenmin Yin, Jing Ma, Biru Wang, Axiu Nie and Heyou Han*. From Electrochemistry to Electroluminescence: Development and Application in Ratiometric Aptasensor for Aflatoxin B1[J]. Analytical Chemistry, 2017, 89(14): 7578-7585. (IF:6.320)[download pdf]

33. Long Wu, Wenmin Yin, Xuecai Tan, Pan Wang, Fan Ding, Huan Zhang, Biru Wang, Weiyun Zhang and Heyou Han*. Direct reduction of HAuCl4 for the visual detection of intracellular hydrogen peroxide based on Au-Pt/SiO2 nanospheres[J]. Sensors and Actuators B: Chemical, 2017, 248: 367-373. (IF:5.401)[download pdf]

34. Huan Zhang, Kai Cai, Pan Wang, Zhao Huang, Jiawei Liu, Long Wu, Mohamed F. Foda and Heyou Han*. Graphene Oxide as a Stabilizer for “Clean” Synthesis of High-Performance Pd-Based Nanotubes Electrocatalysts[J]. ACS Sustainable Chemistry & Engineering, 2017, 5(6): 5191-5199. (IF:5.591)[download pdf]

35.Pan Wang, Long Wu,  Zhicheng Lu, Qing Li, Wenmin Ying, Fan Ding and  Heyou Han*. Gecko-Inspired Nanotentacle SERS Substrate for Rapid Sampling and Reliable Detection of Pesticide Residues in Fruits and Vegetables.Analytical Chemistry, 2017, 89(4): 2424-2431. (IF:6.320)[download pdf]

36. Long Wu, Xiaoyan Xiao, Kun Chen, Wenmin Yin, Qin Li, Pan Wang, Zhicheng Lu, Jing Ma, Heyou Han*Ultrasensitive SERS detection of Bacillus thuringiensis special gene basedon Au@Ag NRs and magnetic beads. Biosensors and Bioelectronics, 2017, 92: 321-327. (IF:7.780)[download pdf]

37. Jiawei Liu, Yue Zheng, Zilan Hong, Kai Cai, Feng Zhao, Heyou Han*. Microbial synthesis of highly dispersed PdAu alloy for enhanced electrocatalysis[J]. Science Advances, 2016, 2(9): e1600858. (IF:11.511)[download pdf]

38. Kai Han, Weiyun Zhang, Jin Zhang, Qi Lei, Shibo Wang, Jiawei Liu, Xianzheng Zhang, and Heyou Han*. Acidity-Triggered Tumor-Targeted Chimeric Peptide for Enhanced Intra-Nuclear Photodynamic Therapy[J]. Advanced functional materials, 2016, 26(24): 4351-4361. (IF:12.124) [download pdf]