课题组老师

prof.han

梁建功,华中农业大学,理学院化学系,教授,硕士生导师,湖北省自然科学基金创新群体核心成员(排名第三),Chem. Commun., J. Phys. Chem. C,Spectrochim. Acta A等杂志审稿人,研究方向为纳米生物分析。先后承担国家自然科学基金面上项目、青年基金、武汉市青年科技晨光计划、湖北省自然科学基金等项目6项。近5年来在J. Phys. Chem. C, J. Nanomater., Spectrochim. Acta A等杂志发表研究论文10余篇。

发表论文:
1. Chengzhi Zheng, Huiping Wang, Wei Xu, Chaoyong Xu, Jiangong Liang*, Heyou Han,Study on the interaction between histidine-capped Au nanoclusters and bovine serum albumin with spectroscopic techniques, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 118: 897–902. 2014.
2. Huiping Wang, Chengzhi Zheng, Tianjiao Dong, Kanglei Liu, Heyou Han, Jiangong Liang*. Wavelength Dependence of Fluorescence Quenching of CdTe Quantum Dots by Gold Nanoclusters, J. Phys. Chem. C 117 (6): 3011-3018, 2013.
3. HuipingWang, Chaoyong Xu, Chengzhi Zheng,Wei Xu, Tianjiao Dong, Kanglei Liu, Heyou Han, and Jiangong Liang*, Facile Synthesis and Characterization of Au Nanoclusters-Silica Fluorescent Composite Nanospheres, Journal of Nanomaterials, 2013: 972834. 2013.
4. 梁建功, 韩鹤友*.量子点的水相合成及其生物成像分析研究进展, 科学通报, 58: 527-530, 2013.
5. Fangfang Xue, Ning Bi, Jiangong Liang*, Heyou Han. A Simple and Efficient Method for Synthesizing Te Nanowires from CdTe Nanoparticles with EDTA as Shape Controller under Hydrothermal Condition. J. Nanomater. 751519, 2012.
6. Fangfang Xue, Jiangong Liang*, Heyou Han. Synthesis and Spectroscopic Characterization of Water-soluble Mn-doped ZnOxS1−x Quantum Dots. Spectrochim. Acta A 83(1): 348-352, 2011.

liangjg@mail.hzau.edu.cn

prof.han

韩凯,华中农业大学,理学院化学系,副研究员,研究方向为基于生物医用材料的肿瘤治疗与成像的研究。2010年6月于武汉大学化学与分子科学学院获得学士学位,2015年6月于武汉大学化学与分子科学学院高分子物理与化学专业获得博士学位,近5年来以第一作者在Adv. Funct. Mater., ACS Nano, Biomaterials, Adv. Healthcare Mater.等杂志发表研究论文9篇。

发表论文:
9. K Han, WY Zhang, J Zhang, Q Lei, SB Wang, JW Liu, XZ Zhang, HY Han,* “Acidity-Triggered Tumor-Targeted Chimeric Peptide for Enhanced Intra-Nuclear Photodynamic Therapy”, Adv. Funct. Mater. 2016, 26: 4351.
8. K Han†, SB Wang†, Q Lei, JY Zhu, XZ Zhang*, “Ratiometric Biosensor for Aggregation-Induced Emission-Guided Precise Photodynamic Therapy”, ACS Nano 2015, 9: 10268.
7. K Han, Q Lei, SB Wang, JJ Hu, WX Qiu, JY Zhu, WN Yin, X Luo, XZ Zhang*, “Dual-Stage-Light-Guided Tumor Inhibition by Mitochondria-Targeted Photodynamic Therapy”, Adv. Funct. Mater. 2015, 25: 2961 (Inside Front Cover Paper).
6. K Han, Q Lei, HZ Jia, SB Wang, WN Yin, WH Chen, SX Cheng, XZ Zhang*, “A Tumor Targeted Chimeric Peptide for Synergistic Endosomal Escape and Therapy by Dual-Stage Light Manipulation”, Adv. Funct. Mater. 2015, 25: 1248.
5. K Han, WN Yin, JX Fan, FY Cao, XZ Zhang*, “Photo-Activatable Substrates for Site-Specific Differentiation of Stem Cells”, ACS Appl. Mater. Inter 2015, 7: 23679.
4. K Han, JY Zhu, SB Wang, ZH Li, SX Cheng, XZ Zhang*, “Tumor Targeted Gold Nanoparticles for FRET-Based Tumor Imaging and Light Responsive On-Demand Drug Release”, J Mater Chem B 2015, 2015, 3: 8065.
3. K Han, Y Liu, WN Yin, SB Wang, Q Xu, RX Zhuo, XZ Zhang*, “A FRET-Based Dual-Targeting Theranostic Chimeric Peptide for Tumor Therapy and Real-Time Apoptosis Imaging”, Adv. Healthcare Mater. 2014, 3: 1765.
2. K Han, S Chen, WH Chen, Q Lei, Y Liu, RX Zhuo, XZ Zhang*, “Synergistic Gene and Drug Tumor Therapy Using a Chimeric Peptide”, Biomaterials 2013, 34: 4680.
1. K Han, J Yang, S Chen, JX Chen, CW Liu, C Li, H Cheng, RX Zhuo, XZ Zhang*, “Novel Gene Transfer Vectors Based on Artificial Recombinant Multi-Functional Oligopeptides”, Int. J. Pharm. 2012, 436: 555.

hank@mail.hzau.edu.cn

prof.han

宋智勇,华中农业大学,理学院化学系,讲师,研究方向为基于纳米材料的生物学效应研究。2008年6月毕业于怀化学院获得工学学士学位,2011年6月毕业于华中农业大学获得理学硕士学位,2015年6月毕业于浙江大学获得理学博士学位。

发表论文:
1. Zhiyong Song, Long Liu, Xiaoyu Wang, Yongqiang Deng, Qinggong Nian, Guangchuan Wang, Shunya Zhu, Xiaofeng Li, Hangyu Zhou, Tao Jiang, Xurong Xu, Ruikang Tang* and Cheng-Feng Qin*, Intracellular delivery of biomineralized monoclonal antibodies to combat viral infection. Chem. Commun., 2016, 52(9): 1879-1882.
2. Zhiyong Song, Xiaoyu Wang*, Genxing Zhu, Qinggong Nian, Hangyu Zhou, Dong Yang, Chengfeng Qin, Ruikang Tang*, Virus Capture and Destruction by Label-Free Graphene Oxide for Detection and Disinfection Applications. Small, 2015, 11(9-10): 1171-1176.
3. Yuesheng Li*, Zhiyong Song, Jiangtao Qin,Haitao Huang,Yan Han. Study on Photocatalytic Degradation of Core/Shell CdSe/ZnS Quantum Dots with Nano-TiO2 by Fluorescent Spectrometric Methods. Chin. J. Anal. Chem., 2016, 44(1): 61–67.
4. Guangchuan Wang, Hongjiang Wang, Hangyu Zhou, Qingong Nian, Zhiyong Song, Yongqiang Deng, Xiaoyu Wang, Sunya Zhu, Xiaofeng Li, Chenfeng Qin*, and Ruikang Tang*, Hydrated Silica Exterior Produced by Biomimetic Silicification Confers Viral Vaccine Heat-Resistance. ACS NANO, 2015, 9(1): 799-808.
5. Guangchuan Wang, Xiaofeng Li, Lijuan Mo, Zhiyong Song, Wei Chen, Yongqiang Deng, Hui Zhao, Ede Qin, Chenfeng Qin*, Ruikang Tang*, Eggshell-inspired biomineralization generates vaccines that do not require refrigeration. Angew. Chem. Int. Ed., 2012, 124(42): 10728-10731.
6. Yongen Lu, Zhiyong Song, Kai Lü, Xinming Lian, Hangmen Cai*, Molecular characterization, expression and functional analysis of the amino acid transporter gene family (OsAATs) in rice. Acta Physiol. Plant, 2012, 34(5): 1943-1962.

songzhiyong@mail.hzau.edu.cn

prof.han

王文静,华中农业大学,理学院化学系,副研究员,研究方向为生物标志物的检测以及成像新方法。2011.09-2017.09 南京大学化学与化工学院, 2015.09-2017.02 美国伊利诺伊大学香槟分校化学系, 2007.09-2011.06 西北大学化学与材料科学学院.

发表论文:
1. Wenjing Wang, Nitya Sai Reddy Satyavolu, Zhenkun Wu, Jian-Rong Zhang, Jun-Jie Zhu* and Yi Lu*, “Near-Infrared photothermal activated DNAzymes-gold nanoshells for imaging metal ions in living cells”, Angew. Chem. Int. Ed., 56, 6798-6802 (2017).
2. Wenjing Wang, Shan Huang, Jingjing Li, Kai Rui, Sai Bi, Jian-Rong Zhang* and Jun-Jie Zhu*, “Evaluation of intracellular telomerase activity through cascade DNA logic gates”, Chemical Science, 8, 174-180 (2017).
3. Wenjing Wang, Jingjing Li, Kai Rui, Panpan Gai, Jian-Rong Zhang* and Jun-Jie Zhu*, “Sensitive electrochemical detection of telomerase activity using spherical nucleic acids gold nanoparticles triggered mimic-hybridization chain reaction enzyme-free dual signal amplification”, Anal. Chem., 87, 3019-3026 (2015).
4. Wenjing Wang, Shan Huang, Jingjing Li, Kai Rui, Jian-Rong Zhang* and Jun-Jie Zhu*, “Coupling a DNA-based machine with glucometer readouts for amplified detection of telomerase activity in cancer cells”, Scientific Reports, 6, 23506 (2016).

wjwang@mail.hzau.edu.cn

prof.han

汪萍,华中农业大学,理学院化学系,2001年毕业于安徽师范大学化学系,2005年5-10月作为博士交换生到香港浸会大学学习,2006年毕业于武汉大学,获博士学位,2008年湖北省优秀博士论文获得者,2009年获全国优秀博士论文提名奖。2006-2010年在美国University of Arizona 从事博士后研究工作,2011年6月来华中农业大学任教。致力于研究小分子与生物大分子相互作用,主要感兴趣领域包括:以DNA为靶位的小分子抗肿瘤药物和以病毒受体为靶的肽类抗病毒药物。

发表论文:
1、 Ping Wang, Renpeng Liu, Xiaojun Wu, Hongjuan Ma, Xiaoping Cao, Ping Zhou, Jianye Zhang, Xiaocheng Weng, Xiao-lian Zhang, Jun Qi, Xiang Zhou and Linhong Weng. A Potent, Water-Soluble and Photoinducible DNA Cross-Linking Agent. J. Am. Chem. Soc. 2003, 125, 1116-1117.
2、 Ping Wang, Yang Song, Lixia Zhang, Hanping He and Xiang Zhou. Quinone methide derivatives: Important intermediates to DNA alkylating and DNA cross – linking actions. Curr Med Chem. 2005, 12(24): 2893-2913.
3、 Ping Wang, Lige Ren, Hanping He, Feng Liang, Xiang Zhou and Zheng Tan, A Phenol Quaternary Ammonium Porphyrin as A Potent Telomerase Inhibitor by Selective Interaction with Quadruplex DNA. Chembiochem, 2006, 7, 1155-1159.
4、 Yang Song , Ping Wang , Juanhuan Wu, Xiang Zhou, Xiaolian Zhang, Linhong Weng, Xiaoping Cao and Feng Liang. Biological Studies of Photoinducible Phenol Quaternary Ammonium Derivatives. Bioorg. Med. Chem. Lett. 2006, 16(6): 1660-1664. (共同第一作者)
5 Xunjin Zhu, Ping Wang, Heidi Wing Chi Leung, WaiKwok Wong, WaiYeung Wong and Daniel WJ Kwong. Synthesis, Characterization, and DNA-Binding and -Photocleavage Properties of Water-Soluble Lanthanide Porphyrinate Complexes. Chem. Eur. J. 2011, 17, 7047-7052.
6 Jackson Porter, Mark Helmers, Ping Wang, Jennifer Furman and Indraneel Ghosh. Profiling Small Molecule Inhibitors against Helix-Receptor Interactions: The Bcl-2 Family Inhibitor BH3I-1 Potently Inhibits p53/hDM2. Chem. Commun. 2010, 46, 8020-8022.

wangping319@mail.hzau.edu.cn

prof.han

刘玲芝,华中农业大学,理学院化学系,副教授,主要从事双光子激发荧光探针及荧光成像方面的研究。2003年7月于华中师范大学化学学院获得学士学位,2010年6月于武汉大学化学与分子科学学院分析化学专业获得博士学位,2010年7月到华中农业大学理学院化学系任教。以第一作者发表SCI源刊论文5篇,包括Anal. Chem., Chem. Commun., Bioconjugate Chem.等国外著名期刊,博士学位论文获得湖北省2011年优秀博士学位论文奖。主持国家自然科学基金青年科学基金项目1项,参加国家自然科学基金项目3项,是湖北省创新团队“动物重大疫病纳米分子成像诊断及其应用基础研究”的骨干成员。

liulingzhi_1981@mail.hzau.edu.cn

prof.han

陈璐,华中农业大学,理学院化学系,讲师,研究方向为分子光谱及纳米生物分析。目前主持国家自然科学基金青年基金项目:“基于无镉量子点的猪繁殖与呼吸综合症病毒检测及细胞成像分析”[2014.1-2016.12],以及校自主科研创新项目:“基于低毒量子点均相免疫检测猪伪狂犬病毒”[2013.9-2014.12]。并参与国家自然科学基金项目:“量子点近红外电致化学发光及其成像研究”[2014.1-2017.12],以及国家自然科学基金项目:“利用荧光金纳米团簇探针研究猪伪狂犬病毒入侵宿主细胞的分子细节”[2014.1-2017.12]。

发表论文:
1. Lu Chen, Xiaowei Zhang, Cuiling Zhang, Guohua Zhou, Wanpo Zhang, Dongshan Xiang, Zhike He,* Hanzhong Wang, Dual-color fluorescence and homogeneous immunoassay for the determination of human enterovirus 71, Analytical Chemistry, 2011, 83(19): 7316-7322.
2.. Lu Chen, Xiaowei Zhang, Guohua Zhou , Xia Xiang, Xinghu Ji, Zhenhua Zheng, Zhike He*, Hanzhong Wang*, Simultaneous identification and determination of human enterovirus 71 and coxsackievirus B3 by dual-color QDs and homogeneous immunoassay, Analytical Chemistry, 2012, 84(7): 3200−3207.
3. Lu Chen, Heyou Han*, Recent advances in the use of near-infrared quantum dots as optical probes for bioanalytical, imaging and solar cell application. Microchimica Acta, 2014, DOI 10.1007/s00604-014-1204-y.
4. Xia Xiang, Lu Chen, Qinggeng Zhuang, Xinghu Ji, and Zhike He*, Real-time luminescence-based colorimetric determination of double-strand DNA in droplet on demand, Biosensors and Bioelectronics, 2012, 32(1): 43-49.
5. Xia Xiang, Lu Chen, Guohua Zhou, Xinghu Ji, and Zhike He*, Homogeneous immunoassay of α-Fetoprotein with a luminescence-based colorimetric droplet platform, Analyst, 2012, 137(24): 5586-5591.
6. 陈璐,吉邢虎,何治柯*,新型荧光技术在病毒检测中的应用,化学传感器,2012, 32(4), 1-8.

chenlu@mail.hzau.edu.cn

prof.han

周媛媛,硕士,华中农业大学,理学院,教师,博士在读。1998年毕业于湖北大学化学与材料科学学院化学教育专业,获理学学士学位,2001年获湖北大学有机化学专业理学硕士学位。主讲课程有《有机化学》、《生物资源化学》、《综合化学实验》等,参编《有机化学》、《基础化学实验》等教材。主要研究领域为生物质能源,纳米催化剂。

zhouyuanyuan@mail.hzau.edu.cn

Lu Donglian

陆冬莲,硕士,华中农业大学理学院讲师/在读博士。1999年毕业于陕西师范大学化学系,获理学学士学位,2002年获陕西师范大学有机化学专业理学硕士学位。主讲课程有《无机及分析化学》、《仪器分析》、《拉曼光谱与电镜技术》等;参编《仪器分析》、《分析化学实验》、《无机化学实验》、《基础化学实验》等教材;主要研究领域为食品安全与纳米生物分析,2011年作为主要成员加入韩鹤友教授带领的湖北省自然科学基金创新群体,参与了多项国家和省级自然科学基金资助项目的研究。

ludonglian@mail.hzau.edu.cn